Explain Science

Colorectal Cancer

Colorectal cancer, sometimes referred to as colorectal carcinoma or colon cancer, is a malignant tumor that arises from the inner lining of the colon (large intestine) or the rectum. It’s the third most common type of cancer worldwide, accounting for a significant number of cancer-related deaths.

The development of colorectal cancer usually starts with the formation of small, noncancerous growths called polyps on the inner lining of the colon or rectum. Over time, some polyps can develop into cancer if they are not detected and removed. This progression generally takes several years, offering a window of opportunity for early detection and intervention.

Although the exact cause of colorectal cancer is unknown, there are several risk factors associated with an increased likelihood of developing the disease. These include age (the risk increases after the age of 50), a personal or family history of colorectal cancer or polyps, genetic mutations such as Lynch syndrome or familial adenomatous polyposis (FAP), a history of inflammatory bowel disease (like Crohn’s disease or ulcerative colitis), a sedentary lifestyle, obesity, a diet high in red or processed meats and low in fiber, smoking, and heavy alcohol consumption.

Detecting colorectal cancer in its early stages is crucial for successful treatment and improved survival rates. Screening tests like colonoscopy, sigmoidoscopy, and fecal occult blood tests can help identify abnormalities or cancerous changes in the colon and rectum. These tests allow for the removal of precancerous polyps or early cancerous lesions before they progress, reducing the risk of mortality.

Treatment options for colorectal cancer depend on various factors, such as the stage and location of the cancer, the overall health of the patient, and their preferences. Surgical procedures to remove the tumor are typically the primary treatment, often combined with chemotherapy, radiation therapy, targeted drug therapy, immunotherapy, or a combination of these approaches. The multidisciplinary care team collaborates to devise an individualized treatment plan that provides the best chance of long-term remission or cure.

While not all cases of colorectal cancer can be prevented, adopting certain lifestyle choices can help reduce the risk. Regular exercise, maintaining a healthy weight, consuming a diet rich in fiber, fruits, and vegetables while limiting processed meats and alcohol, avoiding smoking, and making appropriate use of screening tests can significantly lower the chances of developing colorectal cancer.

By raising awareness about the importance of early detection and healthy habits, we can strive to decrease the burden of colorectal cancer and improve outcomes for those affected by this disease.